There is growing evidence for the antidepressant effects of psychedelics, yet the mechanism underlying these effects are still a mystery. Igor Magaraggia and Rudy Schreiber (of PIM) have suggested a hypothetical model of psychedelics therapeutic mechanism. "After investigating what psychedelics do at the molecular, cellular, and behavioural level, we have suggested a hypothetical model that… Continue reading Improving cognitive functioning in major depressive disorder with psychedelics: A dimensional approach
Ongoing research from our group, presented at Breaking Convention 2019: https://www.youtube.com/watch?v=URSqxFocaas 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) is a psychotropic substance found in various plant as well as animal species, and can also be synthetically produced. Despite the use of 5-MeO-DMT by people in naturalistic settings, current scientific knowledge on the effects of 5-MeO-DMT in humans are relatively… Continue reading Prospective Examination of Synthetic 5-methoxy-N,N-dimethyltryptamine Inhalation
Ongoing research from our group, presented at Breaking Convention 2019: https://www.youtube.com/watch?v=KEGJWxH-jYs Creative thinking and empathy are crucial for everyday interactions and subjective well-being. This is emphasised by studies showing a reduction in these skills in populations where social interaction and subjective well-being is significantly compromised (e.g. depression). Anecdotal reports and recent studies suggest a single… Continue reading (Sub-)Acute Effects of Psilocybin on Creativity, Empathy and Satisfaction with Life
New research from our group, published in Neuropsychopharmacology: Following a double-blind, placebo-controlled, parallel group design, we utilized an ultra-high field multimodal brain imaging approach and demonstrated that psilocybin (0.17 mg/kg) induced region-dependent alterations in glutamate, which predicted distortions in the subjective experience of one’s self (ego dissolution). Whereas higher levels of medial prefrontal cortical glutamate were… Continue reading How Magic Mushrooms Might Dissolve the Ego Revealed
Have you taken a psychedelic in the past 6 months? If so, we are asking for your help! We are interested in how the physical environment (setting) in which you took the substance may have impacted your experience. To do this, we have a short (and completely anonymous) survey asking about your experience. For more… Continue reading Have you taken a psychedelic in the past 6 months? If so, we are asking for your help!