Cannabis, NPS

A comparison of acute neurocognitive and psychotomimetic effects of a synthetic cannabinoid and natural cannabis at psychotropic dose equivalence

Since about 20 years, smoking mixtures, such as Spice or K2, have become popular alternatives for cannabis. These smoking mixtures contain synthetic cannabinoids, which are reported to cause more psychological problems and stronger behavioral impairment. However, comparing the effects of synthetic cannabinoids with natural cannabis has been problematic due to the differences in pharmacological properties… Continue reading A comparison of acute neurocognitive and psychotomimetic effects of a synthetic cannabinoid and natural cannabis at psychotropic dose equivalence

Cannabis

Functional brain connectomes reflect acute and chronic cannabis use

We recently employed resting state fMRI to identify fingerprints of cannabis use history and #cannabis intoxication in the whole brain human connectome. Two distinct data-driven methodologies, i.e. network-based statistics (NBS) and connICA, were used to identify changes in functional brain connectomes collected during placebo and THC exposure in occasional and chronic cannabis users. Whole-brain network… Continue reading Functional brain connectomes reflect acute and chronic cannabis use

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Volunteers wanted to participate in brain imaging after vaporizing cannabis

Maastricht University started a study in the influence cannabis on brain function and is recuiting volunteers to participate. The study consists of 2 test days of about 5 hrs each. During each test day you will receive either cannabis or placebo. Your brain activity will be monitored in an MRI scanner for about 1 hour.… Continue reading Volunteers wanted to participate in brain imaging after vaporizing cannabis

News articles, Uncategorized

Getting high on cannabis makes people vulnerable to ‘false memories’

New research from our group, published in PNAS: In a double-blind, randomised, placebo-controlled study, we show that cannabis increased false memory rates using different false memory methods. The findings have significant legal implications. Read coverage of the publication from Live Science: https://www.livescience.com/cannabis-use-linked-to-false-memories.html

publication, Uncategorized

Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users

New publication out now, in which we used an ultra‚Äźhigh field multimodal brain imaging approach, and showed that in occasional cannabis users, acute THC administration increased striatal glutamate and decreased functional connectivity in the reward system, which were associated with increases in subjective high and decreases in sustained attention. Such changes were absent in chronic… Continue reading Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users