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Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

What is the metabolomic fingerprint of the ayahuasca experience? In a recent study, we collected plasma samples from 23 volunteers both before and during the ayahuasca experience. Samples were screened for concentrations of 164 targeted biomarkers, including endocannabinoids, markers of amino acid metabolism, steroids, ceramindes, etc. What did this fingerprint look like? Changes in serotonin… Continue reading Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

publication

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

The therapeutic potential of psychedelics (psilocybin, LSD, DMT, ayahuasca) is increasingly shown by clinical studies and is proposed to result from increases in neuroplasticity - the brain’s ability to change throughout life. This systematic literature review summarizes the evidence that psychedelics induce neuroplasticity by focusing on psychedelics’ cellular and molecular neuroplasticity effects after single and repeated administration, as investigated in… Continue reading Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

publication

Persisting Effects of Ayahuasca on Empathy, Creative Thinking, Decentering, Personality, and Well-Being

A new study from our group: Collaboration with facilitators of ayahuasca ceremonies throughout the Netherlands has allowed us to assess if Ayahuasca, a psychedelic brew of Amazonian origin, induces persisting short- and long-term effects on emotional and cognitive functioning of healthy volunteers. It was found that 24 hours after participating in an ayahuasca ceremony, participants… Continue reading Persisting Effects of Ayahuasca on Empathy, Creative Thinking, Decentering, Personality, and Well-Being

Podcasts

Exploring Ayahuasca Ceremonies and 5-MeO-DMT Ceremonies- Malin Uthaug

Psychedelics today 21/03/18 Malin Vedøy Uthaug is a Ph.D. candidate at Maastricht University and based out of Prague. Malin joins Psychedelics Today to talk about her interest and research with ayahuasca and 5-MeO-DMT. Malin shares her experience how she got involved studying psychedelics and shares a little bit about her personal experiences with ayahuasca. Malin… Continue reading Exploring Ayahuasca Ceremonies and 5-MeO-DMT Ceremonies- Malin Uthaug

News articles

Waarom ayahuasca kan helpen tegen stress en depressies

Algemeen Dagblad 15/05/2018 Ayahuasca, nog nooit van gehoord? De uitzending van het televisieprogramma Rambam over ayahuasca heeft veel stof doen opwaaien; hallucineren, braken en urenlang trippen. Volgens de programmamakers zouden er vele gevaren aan het gebruik van deze relatief onbekende drug zitten, maar wetenschappers zijn het hier niet volledig mee eens. De drug zou namelijk… Continue reading Waarom ayahuasca kan helpen tegen stress en depressies