Cannabis

Functional brain connectomes reflect acute and chronic cannabis use

We recently employed resting state fMRI to identify fingerprints of cannabis use history and #cannabis intoxication in the whole brain human connectome. Two distinct data-driven methodologies, i.e. network-based statistics (NBS) and connICA, were used to identify changes in functional brain connectomes collected during placebo and THC exposure in occasional and chronic cannabis users. Whole-brain network… Continue reading Functional brain connectomes reflect acute and chronic cannabis use

Uncategorized

Multifaceted Research with Psychedelics @ Maastricht University

We conduct a large variety of studies, all aimed at better understanding psychedelic mechanisms of action, and their clinical applications. To get a glimpse at some of the different aspects of our research, check out the video from our recent symposium, where our PhD candidates share some of the work going on at our department.… Continue reading Multifaceted Research with Psychedelics @ Maastricht University

Uncategorized

Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

What is the metabolomic fingerprint of the ayahuasca experience? In a recent study, we collected plasma samples from 23 volunteers both before and during the ayahuasca experience. Samples were screened for concentrations of 164 targeted biomarkers, including endocannabinoids, markers of amino acid metabolism, steroids, ceramindes, etc. What did this fingerprint look like? Changes in serotonin… Continue reading Metabolomics and integrated network analysis reveal roles of endocannabinoids and large neutral amino acid balance in the ayahuasca experience

NPS

The use patterns of novel psychedelics: experiential fingerprints of substituted phenethylamines, tryptamines and lysergamides

The growing availability and variability of novel psychedelics present new challenges for drug policy, as well as opportunities for clinical research. However, unlike their classic derivatives like psilocybin or lsd, little is known about these drugs. Using an online questionnaire, we asked people what novel psychedelic substances they were using, and what they were experience.… Continue reading The use patterns of novel psychedelics: experiential fingerprints of substituted phenethylamines, tryptamines and lysergamides

NP&PP department, Older adults, Review, SSRI

The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review

SSRIs are still widely prescribed to treat various psychiatric indications even in older adults. The side effects of SSRIs have been characterized in younger adults, but this is not the case for older adults. One concern is that SSRI treatment may contribute to a deterioration of cognitive performance in this older patient population. This systematic… Continue reading The effects of selective serotonin reuptake inhibitors on memory functioning in older adults: A systematic literature review