publication

Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

The therapeutic potential of psychedelics (psilocybin, LSD, DMT, ayahuasca) is increasingly shown by clinical studies and is proposed to result from increases in neuroplasticity - the brain’s ability to change throughout life. This systematic literature review summarizes the evidence that psychedelics induce neuroplasticity by focusing on psychedelics’ cellular and molecular neuroplasticity effects after single and repeated administration, as investigated in… Continue reading Psychedelics and Neuroplasticity: A Systematic Review Unraveling the Biological Underpinnings of Psychedelics

publication, Uncategorized

Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour

Getting a glass of water when you’re thirsty or having a snack when you’re hungry is called goal-directed behaviour. However, when you repeat that behaviour many times the sight of water or a snack may be sufficient to eat and drink. Behaviour is then no longer driven by the goal to alleviate the hunger and/or… Continue reading Dopaminergic and noradrenergic modulation of stress-induced alterations in brain activation associated with goal-directed behaviour

publication

Persisting Effects of Ayahuasca on Empathy, Creative Thinking, Decentering, Personality, and Well-Being

A new study from our group: Collaboration with facilitators of ayahuasca ceremonies throughout the Netherlands has allowed us to assess if Ayahuasca, a psychedelic brew of Amazonian origin, induces persisting short- and long-term effects on emotional and cognitive functioning of healthy volunteers. It was found that 24 hours after participating in an ayahuasca ceremony, participants… Continue reading Persisting Effects of Ayahuasca on Empathy, Creative Thinking, Decentering, Personality, and Well-Being

publication

Improving cognitive functioning in major depressive disorder with psychedelics: A dimensional approach

There is growing evidence for the antidepressant effects of psychedelics, yet the mechanism underlying these effects are still a mystery. Igor Magaraggia and Rudy Schreiber (of PIM) have suggested a hypothetical model of psychedelics therapeutic mechanism. "After investigating what psychedelics do at the molecular, cellular, and behavioural level, we have suggested a hypothetical model that… Continue reading Improving cognitive functioning in major depressive disorder with psychedelics: A dimensional approach

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Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users

New publication out now, in which we used an ultra‐high field multimodal brain imaging approach, and showed that in occasional cannabis users, acute THC administration increased striatal glutamate and decreased functional connectivity in the reward system, which were associated with increases in subjective high and decreases in sustained attention. Such changes were absent in chronic… Continue reading Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users