Cannabis, NPS

A comparison of acute neurocognitive and psychotomimetic effects of a synthetic cannabinoid and natural cannabis at psychotropic dose equivalence

Since about 20 years, smoking mixtures, such as Spice or K2, have become popular alternatives for cannabis. These smoking mixtures contain synthetic cannabinoids, which are reported to cause more psychological problems and stronger behavioral impairment. However, comparing the effects of synthetic cannabinoids with natural cannabis has been problematic due to the differences in pharmacological properties… Continue reading A comparison of acute neurocognitive and psychotomimetic effects of a synthetic cannabinoid and natural cannabis at psychotropic dose equivalence

Cannabis

Functional brain connectomes reflect acute and chronic cannabis use

We recently employed resting state fMRI to identify fingerprints of cannabis use history and #cannabis intoxication in the whole brain human connectome. Two distinct data-driven methodologies, i.e. network-based statistics (NBS) and connICA, were used to identify changes in functional brain connectomes collected during placebo and THC exposure in occasional and chronic cannabis users. Whole-brain network… Continue reading Functional brain connectomes reflect acute and chronic cannabis use

Cannabis

Cannabis Use and Neuroadaptation: A Call for Δ 9 -Tetrahydrocannabinol Challenge Studies.

Currently, the assessment of the neurobehavioral consequences of repeated cannabis use is restricted to studies in which brain function of chronic cannabis users is compared to that of non-cannabis using controls. The assumption of such studies is that changes in brain function of chronic users are caused by repeated and prolonged exposure to acute cannabis… Continue reading Cannabis Use and Neuroadaptation: A Call for Δ 9 -Tetrahydrocannabinol Challenge Studies.