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Healthy males and females who want to participate in a placebo-controlled study on physiological and cognitive effects of Kratom (mitragynine).

Kratom is a plant, native of Eastern countries, that is popular as a novel psychoactive substance (NPS). Its main compound is mitragynine (MG). The purpose of this study is to asses the physiological and cognitive effects of mitragynine in healthy subjects (phase 1 study). The study consists of 4 test days of ± 7.5 hours each, over a period of 6 weeks. On separate test days, you will receive placebo (inactive substance) and 3 doses of mitragynine. Your physical functions will be monitored at regular intervals up to 7 hours after administration by a medical supervisor, in order to determine safety of the treatment. In addition, you will perform several computer tasks and fill out some questionnaires. Blood samples will be taken through an intravenous cannula at baseline, during and at the end of the test day. Also urine samples will be collected at baseline and at the end of the test day. Prior to participating you will fill out a medical and drug use questionnaire online. You will also undergo a medical check-up and computer tasks will be practiced.

Compensation for full participation: €415*

* In the event of early termination, the amount is calculated on the number of hours invested

What are the requirements?

You are between 18 and 45 of age and you are healthy

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