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Reduced responsiveness of the reward system is associated with tolerance to cannabis impairment in chronic users

New publication out now, in which we used an ultra‐high field multimodal brain imaging approach, and showed that in occasional cannabis users, acute THC administration increased striatal glutamate and decreased functional connectivity in the reward system, which were associated with increases in subjective high and decreases in sustained attention. Such changes were absent in chronic cannabis users. Findings suggest the development of neuroadaptations in reward circuitry after excessive use of cannabis, which may underlie behavioral tolerance to the drug.

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